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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKM
All Species:
21.52
Human Site:
S477
Identified Species:
39.44
UniProt:
P08237
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P08237
NP_000280.1
780
85183
S477
K
R
T
L
P
K
K
S
F
E
Q
I
S
A
N
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
Q476
K
R
T
L
P
K
G
Q
L
E
S
I
V
E
N
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
S548
K
R
T
L
P
K
K
S
F
E
Q
I
S
A
N
Dog
Lupus familis
XP_544922
751
82459
Y447
K
R
T
L
P
R
S
Y
M
E
K
I
V
D
N
Cat
Felis silvestris
Mouse
Mus musculus
P47857
780
85250
N477
K
R
T
L
P
K
K
N
L
E
Q
I
S
A
N
Rat
Rattus norvegicus
P47858
780
85541
N477
K
R
T
L
P
K
K
N
L
E
Q
I
S
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511162
864
94802
Y558
K
R
T
L
P
A
K
Y
L
E
Q
I
A
E
Q
Chicken
Gallus gallus
NP_989554
769
83907
Y464
K
R
T
L
P
K
K
Y
F
E
E
I
S
A
T
Frog
Xenopus laevis
NP_001086921
808
88294
Y505
K
R
T
L
P
K
K
Y
F
E
E
I
S
N
N
Zebra Danio
Brachydanio rerio
NP_001004575
784
85614
Y478
K
R
L
L
P
G
K
Y
M
E
E
I
S
L
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
K486
K
R
T
L
P
E
G
K
F
K
E
I
A
A
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
M480
K
R
Q
L
P
S
E
M
D
L
I
A
E
G
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
A664
N
R
V
T
P
E
E
A
D
L
G
M
I
A
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.5
90.4
67.6
N.A.
97.8
96.6
N.A.
65.2
81.2
81.4
77.8
N.A.
58.7
N.A.
39.6
N.A.
Protein Similarity:
100
82.8
91.1
81.7
N.A.
99
98.2
N.A.
76.2
90.1
90.3
88.7
N.A.
75.7
N.A.
57.6
N.A.
P-Site Identity:
100
60
100
53.3
N.A.
86.6
86.6
N.A.
60
80
80
60
N.A.
53.3
N.A.
26.6
N.A.
P-Site Similarity:
100
60
100
66.6
N.A.
93.3
93.3
N.A.
66.6
86.6
86.6
66.6
N.A.
80
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
8
0
0
0
8
16
54
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
16
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
16
16
0
0
77
31
0
8
16
0
% E
% Phe:
0
0
0
0
0
0
0
0
39
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
8
16
0
0
0
8
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
85
8
0
0
% I
% Lys:
93
0
0
0
0
54
62
8
0
8
8
0
0
0
0
% K
% Leu:
0
0
8
93
0
0
0
0
31
16
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
8
16
0
0
8
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
16
0
0
0
0
0
8
62
% N
% Pro:
0
0
0
0
100
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
8
0
0
39
0
0
0
8
% Q
% Arg:
0
100
0
0
0
8
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
8
8
16
0
0
8
0
54
0
0
% S
% Thr:
0
0
77
8
0
0
0
0
0
0
0
0
0
0
8
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
39
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _